日本語総説等

• バイオ医薬のための受託の展望 (2011)　勝村泰彦、「ジェネリック医薬品業界の国内・海外動向と開発情報」、シーエムシー出版
• タンパク質生産システムASPEXの開発〜タンパク質製造企業への挑戦〜 (2010)　熊谷博道、　化学と生物、 Vol48, 794-798.
• バイオ原薬製造における重要工程プロセスパラメータ等の設定に関して (2010)　勝村泰彦、PHARMSTAGE　9、36-39
• 細胞培養における培地設計について (2010)　勝村泰彦、　抗体医薬のための細胞構築と培養技術、シーエムシー出版
• 分裂酵母S.pombeの産業利用　〜その秘められた可能性〜 (2009)　浜祐子、熊谷博道、バイオサイエンスとインダストリー　Vol67,　250-253.
• バイオ医薬品製造設備の設計と運用 (2009)　礒合敦 PHARMSTAGE　9、34-40
• 細胞株構築から培養工程までの実際と留意点 (2009)　勝村泰彦、「抗体医薬品における規格試験法・製造と承認申請」サイエンス＆テクノロジー
• 効率的な抗体医薬品製造技術 (2008)　礒合敦、勝村泰彦、熊谷博道、塚本洋子、「抗体医薬品研究開発ノウハウ集2008」、技術情報協会
• 分裂酵母のミンマムゲノムファクトリー (2007)　浜　祐子、竹川薫、「微生物機能を活用した革新的生産技術の最前線―ミニマムゲノムファクトリーとシステムバイオロジー―」、シーエムシー出版
• ＧＭＰ製造設備における適格性評価基準−バイオ原薬製造設備における適格性評価− (2007)　吉武彰文　PHARMSTAGE　7(4), 33-38
• 分裂酵母異種タンパク質生産系の構築とその改良 (2007)、東田英毅、酵素工学ニュース 57, 24-32
• Latour system：染色体改変技術を応用した新たな必須遺伝子判定法 (2008)　平島匡太郎、東田英毅、バイオテクノロジージャーナル、 26, 458-461
• 分裂酵母のポストゲノム研究：最小ゲノムセットを持ったモデル真核生物 (2004)　東田英毅、浜（儀我）祐子、竹川薫、バイオサイエンスとインダストリー 62: 28-31
• 「抗体医薬品」をはじめとしたバイオ医薬品製造の現状と課題 (2004)　熊谷博道、PHARMSTAGE、 vol.4. 49-56.
• 分裂酵母（ Schizosaccharomyces pombe ）による蛋白質生産 (2002)　熊谷博道、細胞、 3月号
• 有用たんぱく質の製造技術-ASPEXを中心に- (2000)　熊谷博道、化学経済、Vol12

オリジナル論文

• Processing and maturation of carboxypeptidase Y and alkaline phosphatase in Schizosaccharomyces pombe. (2011) Mukaiyama H, Iwaki T, Idiris A, Takegawa K. Appl. Microbiol. Biotechnol. 90:203-213.
• New insights into galactose metabolism by Schizosaccharomyces pombe: isolation and characterization of a galactose-assimilating mutant. (2011) Matsuzawa T, Fujita Y, Tanaka N, Tohda H, Itadani A, Takegawa K. J. Biosci. Bioeng. 111:158-166.
• Engineering of protein secretion in yeast: strategies and impact on protein production. (2010) Idiris A, Tohda H, Kumagai H, Takegawa K. Appl. Microbiol. Biotechnol. 86:403-417.
• The gld1+ gene encoding glycerol dehydrogenase is required for glycerol metabolism in Schizosaccharomyces pombe. (2010) Matsuzawa T, Ohashi T, Hosomi A, Tanaka N, Tohda H, Takegawa K. Appl. Microbiol. Biotechnol. 87:715-727.
• Overexpression of protein disulfide isomerases enhances secretion of recombinant human transferrin in Schizosaccharomyces pombe. (2010) Mukaiyama H, Tohda H, Takegawa K. Appl. Microbiol. Biotechnol. 86:1135-1143.
• Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway. (2010) Idiris A, Tohda H, Sasaki M, Okada K, Kumagai H, Giga-Hama Y, Takegawa K. Appl. Microbiol. Biotechnol. 85:667-677.
• Mug28, a meiosis-specific protein of Schizosaccharomyces pombe, regulates spore wall formation. (2010) Shigehisa A, Okuzaki D, Kasama T, Tohda H, Hirata A, Nojima H. Mol. Biol. Cell. 21:1955-1967.
• Dextran sodium sulfate enhances secretion of recombinant human transferrin in Schizosaccharomyces pombe. (2009) Mukaiyama H, Giga-Hama Y, Tohda H, Takegawa K. Appl. Microbiol. Biotechnol. 85:155-164.
• The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides. (2009) Ohashi T, Ikeda Y, Tanaka N, Nakakita S, Natsuka S, Giga-Hama Y, Takegawa K. Biosci. Biotechnol. Biochem. 73:407-414.
• Production of heterologous proteins using the fission-yeast (Schizosaccharomyces pombe) expression system. (2009) Takegawa K, Tohda H, Sasaki M, Idiris A, Ohashi T, Mukaiyama H, Giga-Hama Y, Kumagai H. Biotechnol. Appl. Biochem. 53(Pt 4):227-235.
• Characterization of a sHsp of Schizosaccharomyces pombe, SpHsp15.8, and the implication of its functional mechanism by comparison with another sHsp, SpHsp16.0.(2009) Sugino C, Hirose M, Tohda H, Yoshinari Y, Abe T, Giga-Hama Y, Iizuka R, Shimizu M, Kidokoro S, Ishii N, Yohda M. Proteins 74:6-17.
• The gap-filling sequence on the left arm of chromosome 2 in fission yeast Schizosaccharomyces pombe. (2008) Sasaki M, Idiris A, Tada A, Kumagai H, Giga-Hama Y, Tohda H. Yeast 25:673-679.
• Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe. (2008) Iwaki T, Iefuji H, Hiraga Y, Hosomi A, Morita T, Giga-Hama Y, Takegawa K. Microbiology 154(Pt 3):830-841.
• Schizosaccharomyces pombe minimum genome factory. (2007) Giga-Hama Y, Tohda H, Takegawa K, Kumagai H. Biotechnol. Appl. Biochem. 46(Pt 3):147-155.
• Atf1 is a target of the mitogen-activated protein kinase Pmk1 and regulates cell integrity in fission yeast. (2007) Takada H, Nishimura M, Asayama Y, Mannse Y, Ishiwata S, Kita A, Doi A, Nishida A, Kai N, Moriuchi S, Tohda H, Giga-Hama Y, Kuno T, Sugiura R. Mol. Biol. Cell. 18:4794-4802.
• Essential roles of class E Vps proteins for sorting into multivesicular bodies in Schizosaccharomyces pombe. (2007) Iwaki T, Onishi M, Ikeuchi M, Kita A, Sugiura R, Giga-Hama Y, Fukui Y, Takegawa K. Microbiology. 153(Pt 8):2753-2764.
• Loss of a GPI-anchored membrane protein Aah3p causes a defect in vacuolar protein sorting in Schizosaccharomyces pombe. (2007) Iwaki T, Morita T, Tanaka N, Giga-Hama Y, Takegawa K. Biosci. Biotechnol. Biochem. 71:623-626.
• Two endoplasmic reticulum-associated degradation (ERAD) systems for the novel variant of the mutant dysferlin: ubiquitin/proteasome ERAD(I) and autophagy/lysosome ERAD(II). (2007) Fujita E, Kouroku Y, Isoai A, Kumagai H, Misutani A, Matsuda C, Hayashi YK, Momoi T. Hum. Mol. Genet. 16:618-629.
• ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. (2007) Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. Cell Death Differ. 14:230-239.
• Enhanced productivity of protease-sensitive heterologous proteins by disruption of multiple protease genes in the fission yeast Schizosaccharomyces pombe. (2006) Idiris A, Tohda H, Bi KW, Isoai A, Kumagai H, Giga-Hama Y. Appl. Microbiol. Biotechnol. 73:404-420.
• Construction of a protease-deficient strain set for the fission yeast Schizosaccharomyces pombe, useful for effective production of protease-sensitive heterologous proteins. (2006) Idiris A, Bi K, Tohda H, Kumagai H, Giga-Hama Y. Yeast 23:83-99.
• Vacuolar protein sorting receptor in Schizosaccharomyces pombe. (2006) Iwaki T, Hosomi A, Tokudomi S, Kusunoki Y, Fujita Y, Giga-Hama Y, Tanaka N, Takegawa K. Microbiology 152(Pt 5):1523-1532.
• A simple and effective chromosome modification method for large-scale deletion of genome sequences and identification of essential genes in fission yeast. (2006) Hirashima K, Iwaki T, Takegawa K, Giga-Hama Y, Tohda H. Nucleic Acids Res. 34(2):e11.
• Heat shock-inducible expression vectors for use in Schizosaccharomyces pombe. (2006) Fujita Y, Tohda H, Giga-Hama Y, Takegawa K. FEMS Yeast Res. 6:883-887.
• A survey of all 11 ABC transporters in fission yeast: two novel ABC transporters are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. (2006) Iwaki T, Giga-Hama Y, Takegawa K. Microbiology 152(Pt 8):2309-2321.
• An alpha-amylase homologue, aah3, encodes a GPI-anchored membrane protein required for cell wall integrity and morphogenesis in Schizosaccharomyces pombe. (2006) Morita T, Tanaka N, Hosomi A, Giga-Hama Y, Takegawa K. Biosci Biotechnol Biochem. 70:1454-1463.
• Homocysteine accumulation causes a defect in purine biosynthesis: further characterization of Schizosaccharomyces pombe methionine auxotrophs. (2006) Fujita Y, Ukena E, Iefuji H, Giga-Hama Y, Takegawa K. Microbiology. 152(Pt 2):397-404.
• Spsgt1, a new essential gene of Schizosaccharomyces pombe, is involved in carbohydrate metabolism. (2006) Kainou T, Shinzato T, Sasaki K, Mitsui Y, Giga-Hama Y, Kumagai H, Uemura H. Yeast 23:35-53.
• A distinct type of alcohol dehydrogenase, adh4+, complements ethanol fermentation in an adh1-deficient strain of Schizosaccharomyces pombe. (2004) Sakurai M, Tohda H, Kumagai H, Giga-Hama. FEMS Yeast Res. 4:649-654.
• Production of recombinant human lysosomal acid lipase in Schizosaccharomyces pombe: development of a fed-batch fermentation and purification process. (2004) Ikeda S, Nikaido K, Araki K, Yoshitake A, Kumagai H, Isoai A. J. Biosci. Bioeng. 98:366-373.
• Production of D-amino acid oxidase (DAO) of Trigonopsis variabilis in Schizosaccharomyces pombe and the characterization of biocatalysts prepared with recombinant cells. (2002) Isoai A, Kimura H, Reichert A, Schörgendorfer K, Nikaido K, Tohda H, Giga-Hama Y, Mutoh N, Kumagai H. Biotechnol. Bioeng. 80:22-32.
• Detection of caspase-9 activation in the cell death of the Bcl-x-deficient mouse embryo nervous system by cleavage sites-directed antisera. Fujita E, Urase K, Egashira J, Miho Y, Isahara K, Uchiyama Y, Isoai A, Kumagai H, Kuida K, Motoyama N, Momoi T. (2000) Brain Res. Dev. Brain Res. 122:135-147.

著書

• Foreign Gene Expression in Fission Yeast Schizosaccharomyces pombe, Giga-Hama, Y. and Kumagai H., eds.,1997, Springer-Verlag, Berlin